An αIIbβ3- and phosphatidylserine (PS)-binding recombinant fusion protein promotes PS-dependent anticoagulation and integrin-dependent antithrombosis
نویسندگان
چکیده
منابع مشابه
Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells
Efficient phagocytosis of apoptotic cells is important for normal tissue development, homeostasis, and the resolution of inflammation. Although many receptors have been implicated in the clearance of apoptotic cells, the roles of these receptors in the engulfment process have not been well defined. We developed a novel system to distinguish between receptors involved in tethering of apoptotic c...
متن کاملFacilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase.
A cationic steroid with a hydrogen-bonding pocket that has an affinity for anionic phospholipid headgroups was synthesized and shown to strongly promote the translocation or flip-flop of a fluorescent, C(6)NBD-labeled phosphatidylserine probe (C(6)NBD-PS) across vesicle membranes. In addition, the synthetic PS scramblase increases the levels of endogenous PS on the surface of erythrocytes as mo...
متن کاملPhosphatidylserine (PS) and Age-Related Cognitive Decline (ARCD)
1. Age-Related Cognitive Decline (ARCD) Age related cognitive decline (ARCD) [1] is the scientific term for memory loss in elderly people who are clinically healthy. It is a physiological process associated with aging, not a disease, and occurs during middle life or later. Many people who are clinically healthy find as they get into their forties or fifties, sometimes even as early as their thi...
متن کاملComparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry.
The exogenous introduction of a molecular species mixture of bovine cortex phosphatidylserine (BC-PS) has been claimed to improve memory function in subjects suffering from age-associated memory impairment and dementia. However, it has been also reported that oral administration of another molecular species mixture of transphosphatidylated-soybean phosphatidylserine (T-Soy-PS) showed a little e...
متن کاملCleaved protein S (PS), total PS, free PS, and activated protein C cofactor activity as risk factors for venous thromboembolism.
BACKGROUND Although hereditary protein S (PS) deficiency is clearly associated with venous thromboembolism (VTE), the importance of low PS concentrations as a risk factor for VTE in other patients is still a matter of debate. To clarify this issue, we designed a case-control study to evaluate the role of different molecular forms of plasma PS. METHODS We quantified plasma cleaved, total, and ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.006044